Milk Thistle (LEGALON)
Pharmacological studies for milk thistle as a antioxidant boasting anti-inflammatory, anti-fibrotic, and anti-cancer properties. Many pharmacological studies comprise inhibition of lipid peroxidation and excitement of protein biosynthesis. But, the bulk of the literature concerns the hepatoprotective effectiveness of silibinin and silymarin in particular against Amanita phalloides mushroom poisoning.
Legalon 70 is a medication acting on the liver. It strengthens practical efficiency and the regenerative capability of the liver. Most oral steroids are possibly poisonous to the liver, even brief durations can find raised rates of toxins in the liver. Protect and Legalon 70 will help detoxify the liver, ultimately making the employment of oral steroids safer for the liver. Legalon is the result of many decades of intensive research by Madaus. The active ingredient is silymarin, with its main active component silibinin. Extensive research within this infusion over the last 20 years has conclusively shown that this infusion is beneficial in detoxifying and protecting the liver. You can start the treatment with 70 capsules, unless your physician has directed otherwise. It should be taken in a dose of 2 capsules, 3 times daily in serious cases. The capsules should be swallowed whole with a little bit of liquid. Legalon is an herbal medicine. In general, herbal medicines are effective in nature. It is definitely true with Legalon. It is often used for the therapy of liver diseases for nearly 30 years. As regards side effects, a mild laxative activity has sometimes been noted. This has been the advantage of the active agent– silymarin, as it is more immediately absorbed in the body. It may also act efficiently and more swiftly. Should any gastrointestinal difficulties happen, you can get Legalon during or following meals.
More Info on uses and Research of Milk thistle
A literature review in Germany noted that Legalon is the top official agent for the therapy of poisonous liver damage (Morazzani and Bombardelli, 1995). These writers also reviewed studies which indicate future use in cosmetic and dermatological products. It predicated on several tasks including encouraging healing enhanced burn healing, at wound sites, and counteracting skin degeneration and aging via anti-inflammatory and free-radical scavenging mechanisms.
In a double blind, placebo-controlled study, the effectiveness of silymarin was assessed in patients receiving psychotropic drugs as long term treatment (Palasciano et al., 1994). Sixty girls in the psychiatric ward of an Italian hospital were chosen for the trial. All have been treated with either for phenothiazines and/or butyrophenones at least five years. They were randomly split into four groups, together with the silymarin patients receiving 800 milligrams a day for 90 days. Results revealed that 800 mg/day of silymarin might be helpful in the therapy of some cases of lipoperoxidative hepatic damage. It includes the damage that could happen during long term treatment together with the psychotropic drugs.
Milk thiste (Legalon) Popularity
Milk thistle extract has become increasingly popular in the United States as a dietary supplement for people with livers compromised by alcohol or exposure to toxic chemicals. Based on the increasing number of clinical studies indicating its safety and suggesting efficacy, consumers are also using this preparation as a means to ensure proper liver function and to assist in “detoxification” measures. Given this phytomedicine”s well established safety and its reasonable documentation of efficacy, future clinical use of milk thistle extract should be explored as an adjunct therapy in chemotherapy to help offset the effects of powerful and potentially hepatotoxic conventional drugs.
U.S. pharmacopeial grade milk thistle consists of the dried ripe fruit of S. marianum with its pappus removed. It must contain not less than 2% of silymarin, calculated as silybin, as determined by a USP spectrophotometric assay method. Botanical identification must be confirmed by thin-layer chromatography (TLC) and macroscopic and microscopic examinations (USP 24a??NF 19, 1999). German pharmacopeial grade milk thistle also consists of the ripe fruit with the pappus removed. However, it must contain not less than 1.5% silymarin, calculated as silybin with reference to the dried drug. Total silymarin must be determined by a liquid chromatagraphic method (DAB method V.6.20.4). Botanical identity must be confirmed by TLC, macroscopic and microscopic examinations, and organoleptic evaluations. For example, the seed husk should have a bitter taste while the seed has an oleaginous taste, and it may not smell or taste rancid (DAB, 1997). The German Homeopathic Pharmacopoeia monograph requires that it contain not less than 1% of silymarin, calculated as silybin .